Olfactory receptor modulates glucose homeostasis
Professor Yiguo Wang’s group at School of Life Sciences, Tsinghua University, published a research article entitled "OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin" in Cell Metabolism on 20th June, 2019. In this work, Prof. Wang’s group revealed that the olfactory receptor OLFR734 promotes hepatic glucose production as a receptor of Asprosin.
OLFR734 mediates glucose metabolism as a receptor of Asprosin
Asprosin is a fasting-induced hormone that promotes glucose production in the liver and stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor. However, the bona fide receptor of Asprosin is unclear. Here, Prof. Wang’s group has identified that the olfactory receptor OLFR734 acts as a receptor of Asprosin to modulate hepatic glucose production. Olfr734 knockout mice show a blunted response to Asprosin, including attenuated cAMP levels and hepatic glucose production, and improved insulin sensitivity. As Olfr734 deficiency dramatically attenuates both fasting and high-fat-diet-induced glucose production, this work demonstrates a critical role of OLFR734 as a receptor of Asprosin to maintain glucose homeostasis during fasting and in obesity.
Professor Yiguo Wang is the corresponding author of this work. Erwei Li, Haili Shan, Liqun Chen, Aijun Long and Yuanyuan Zhang are the co-first authors. This work was supported by grants from the Ministry of Science and Technology of the People’s Republic of China (2016YFC1304803 and 2017YFA0503404), the National Natural Science Foundation of China (31625014, 31621063, and 31830040) and Beijing Advanced Innovation Center for Structural Biology.
Source: School of Life Sciences
Editor: Guo Lili
